NOD2 interaction with distinct NLRP members.

Abstract

<p><i>Upper panel</i>, A “+” indicates an interaction, “−” symbolizes no interaction (n.d.: not done). A short isoform of NOD2 (NOD2-S, residues 1–180), maintains the interaction with NLRP1, -3, and -12. Furthermore, a linker region within NLRP1 (residues 92–341) proved sufficient for interaction with NOD2. <i>Lower panel</i>, Schematic illustration of particular NOD2/NLRP1 constructs and their respective interactions. FIIND: Function to find domain.</p