A schematic representation of cancer-specific alternative gene splicing.

Abstract

<p>(a) Oncogene, (b) tumor suppressor gene. The alternative splicing of RAF1 generates a lung cancer-specific transcript, whereas the alternative splicing of FOS produces an uterus cancer-specific transcript. Tumor suppressor GLTSCR2 is alternatively spliced to produce two retinoblastoma-specific transcripts and EMP3 to generate a skin cancer-specific transcript. Deleted domains are shown with blue arrows. Arrows with a right angle indicate the start codon, ATG.</p