Mice immunized with vGK5 are protected from a lethal challenge with VACV-WR.
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Abstract
<p>Mice were infected with 10<sup>4.5</sup>, 10<sup>6</sup> PFU of vGK5 (n = 3/group) by the intranasal route. 1 month later immunized mice and age matched naïve controls were challenged with a lethal dose of VACV-WR (10<sup>6</sup> PFU) by the i.n. route. (A) Weights of mice were monitored over 5 days. Viral titers were measured in the (B) lungs and (C) ovaries and expressed as viral titers/gm lung tissue or ovaries. Each symbol represents the titer obtained in target organs of individual mice.</p
