Con A induced hepatitis is alleviated in B7- and CD28- deficient mice.

Abstract

<p>Eight-week old B7KO, CD28KO and C57BL/6 mice received intravenous injection of Con A at a dose of 20 mg/kg. Sixteen hours later, serum and liver tissues from individual mice were harvested. A. Serum ALT and AST levels. B. One representative section from each group showing the pattern of liver injury. C. Average percentages of area with injuries from 3–4 sections per mouse and 4–5 mice per group.</p