<p>Regulons include sets of genes that are known to be directly controlled by a particular regulatory gene. The <i>y</i>-axis shows the significance level of the change in a regulon's dependence on <i>crp</i> in an evolved background relative to the ancestor, where a double Z-score value of 2 corresponds to a <i>p-</i>value of ∼0.05. The 135 regulons characterized in E. coli are arranged alphabetically along the <i>x</i>-axis, but only those regulons that changed significantly in both evolved lines are listed by name. Blue and red symbols indicate regulons that became significantly more or less sensitive, respectively, to the <i>crp</i> deletion in an evolved background. See text for additional information.</p
