Cumulative Distribution Functions Illustrating Proteome-Wide Trends in Protein Similarity

Abstract

<p><i>x</i>-axis, bits/aligned position; <i>y</i>-axis, cumulative fraction of HSPs having that number of bits/aligned amino acid pair or less. To facilitate display, only a subset of the 21 possible pair-wise combinations is shown. Data are based upon all reciprocal best BLASTP hits identified in all versus all BLASTP searches of the proteomes. Similarity calculations were restricted to the high-scoring HSP for each BLAST hit, in order to avoid data duplication due to overlapping alignments.</p> <p>There were 13,339 <i>M. musculus–H. sapiens</i> reciprocal best hits; 6,435 between D. melanogaster and <i>A. gambiae;</i> 5,828 between C. intestinalis and <i>H. sapiens;</i> 5,542 between D. melanogaster and <i>H. sapiens;</i> 4,669 between C. elegans and <i>H. sapiens;</i> 4,588 between C. elegans and <i>D. melanogaster;</i> 3,361 between H. sapiens and <i>A. thaliana;</i> and 2,835 between C. elegans and A. thaliana.</p> <p>atha, <i>A. thaliana;</i> cele, <i>C. elegans;</i> cint, <i>C. intestinalis;</i> dmel, <i>D. melanogaster;</i> hsap, <i>H. sapiens;</i> mmus, <i>M. musculus.</i></p