IT Administration of A<sub>2A</sub>R Agonist Protects from Increased Death Rate upon Oxygenation of Mice with Acute Lung Injury

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    Abstract

    <p>Compensation for the oxygenation-associated loss of the hypoxia → adenosine → A<sub>2A</sub>R signaling pathway by IT injection of CGS21680 significantly decreased the oxygen-exacerbated death rate in mice with acute lung injury induced by IT injection of SEB and LPS. For further explanation, see legend for <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030174#pbio-0030174-g001" target="_blank">Figure 1</a>.</p

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      Last time updated on 12/02/2018