Conceptual model of TBC1D15 function in TISC-mediated oncogenesis.
- Publication date
- Publisher
Abstract
<p>The transition from an untransformed hepatocyte to a TISC is accompanied by an anabolic shift and increased levels of the TBC1D15 oncoprotein, which destabilizes the Numb-p53 complex to promote deregulated self-renewal and oncogenesis.</p