Hepatic RNA microarray analysis of <i>Iqgap2^−/−</i> mice.

Abstract

<p><b>A</b>: Schema of a four-way microarray analysis of <i>Iqgap2^−/−</i> knockout (KO) and wild-type (WT) mouse livers at 6 months and 24 months of age. Four-way comparison using SAM identified 554 genes that were differentially expressed among four groups (cutoff fold change ≥3 and FDR≤0.05). <b>B</b>: Unsupervised hierarchical cluster analysis identified 11 subsets of genes (clusters) within 554 genes that change expression in similar pattern across four groups; <b>C</b>: Top canonical biological pathways for genes from the cluster # 9 as identified by Ingenuity Pathway Analysis (IPA).</p