<p>A, scores plot of the OPLS-DA model for the untreated and treated tumors, which shows the group separation among the untreated (square), free drug-treated (circle) and micellar drug-treated (diamond) tumors. The percentages of explained variation modeled for the first two components (OPLS1 and OPLS2) are displayed on the axes. B, there was no clear correlation between the OPLS1 scores and their corresponding tumor weights. C, Student’s t-test filtered difference NMR spectra (p<0.05) of tumors treated with paclitaxel/17-AAG combination in the free forms (top) and in the micellar formulation (bottom). The positive peaks correspond to the metabolites increased in concentration relative to the untreated tumors, whereas the negative peaks are from the metabolites decreased. The identified metabolites are: Glc, glucose; Cho, choline; Crt, creatine; Asp, aspartate; Gln, glutamine; Glu, glutamate; Ala, alanine; Lac, lactate.</p
