Representative examples of HuR immunoreactivity in normal urothelial cells (A; magnification, ×200.) and cancer cells (B and C; magnification, ×400.).

Abstract

<p>HuR was mainly detected in nuclei of both normal and cancer cells in bladder tissues. Moderate or strong cytoplasmic expression was evident in cancer cells (C), but was rare in normal urothelial cells (A). Some cancer cells are also showed weak cytoplasmic expression although nuclear expression was detected (B). In addition, we showed representative figures of HuR expression (C) and factors related thereto; (D) cyclooxygenase-2, (E) vascular endothelial growth factor-A, (F) vascular endothelial growth factor-C in same area. (all magnification, x400).</p