The changes of cytokines IL-4, IL-10, IFN-γ and IL-2 in NALF (A) and BALF (B).

Abstract

<p>As shown above, administration of <i>E. coli</i> exhibited significant inhibition of levels of Th2 cytokines IL-4. Interestingly, the effect was accompanied by high levels of Th1 cytokines IFN-γ and IL-2, as well as the increased production of IL-10 secreted abundantly by Tregs. Additionally, the effects were more significant in neonatal mice infected with 10⁸CFU <i>E. coli</i>. Data is represented as the mean secretion pg/ml ± SEM, n = 8∼10.^*<i>p</i><0.05, ^**<i>p</i><0.01 as conducted.</p