EcTI and its complex with trypsin.

Abstract

<p>(a) Ribbon representation of the overall three-dimensional structure of EcTI. β-strands labeled β1–12 are shown in red, and loops labeled L1–13 are in green. Loop L10 is only marked for consistency with the other related structures, since the main chain is broken in this region. (b) Pseudo-dimer of the two crystallographically independent molecules of EcTI in the asymmetric unit. The main contact loops are labeled. (c) Overall structure of the EcTI-trypsin complex shown as a cartoon diagram. EcTI is colored green, while trypsin is red, and the reactive loop is labeled.</p