WebLogo of Amino Acid Sequence of Circumsporozoite Protein from Malawi and the Gambia.

Abstract

<p>Panel A and Panel B are the Weblogos for Malawi and the Gambia, respectively. In Panel A, the TH2 region (blue) and TH3 region (pink) are underlined. The TH2 epitope maps almost exclusively to the α-helix, while the TH3 epitope maps to the flap. The polymorphic residues and types of amino acids that populate these sites appear to be conserved between two geographically disparate African parasite populations. Bits represent the information content, which is a relative measurement of sequence conservation, with higher values representing conservation and lower values consistent with sequence diversity at a position.</p