TH2 and TH3 Pairings from Malawi and the Gambia.

Abstract

<p>(a) This figure shows all TH2-x/TH3-y haplotype pairings comparing observed and expected. Those that are that are statistically over and under represented based upon our contingency table analysis (p≤0.00009 for Malawi and p≤0.003 for the Gambia) are colored blue. (b) The data shown are for those pairings in Malawi (blue) and the Gambia (green) that are either observed >5 times in our data, or those predicted to occur >5 times based upon our contingency analysis. Each pairing is represented a unique symbol. Of note, three pairings (TH2-1/TH3-1, TH2-6/TH3-1, and TH2-3/TH3-2) were over represented in both populations. In both figures, the diagonal line represents if there were non-random association of pairings based on predicted and observed values. Points above the line represent pairing over represented in the population, while those represented below the line are those under represented in the population. A complete list of these significant pairings is provided in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0062427#pone.0062427.s005" target="_blank">Table S2</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0062427#pone.0062427.s006" target="_blank">S3</a>.</p