Schematic illustration of amyloid fibril formation in the presence of a lipid membrane.

Abstract

<p>In the majority of published studies, the processes illustrated in (A) are investigated, including studies of the aggregation process (monomeric protein, via transient oligomeric aggregates to amyloid fibrils), and studies of how proteins in different aggregation stages adsorbs to and modify lipid membranes. In the present study, we focus on another aspect of the amyloid formation process, that is co-aggregation and the possibility of lipid uptake from the membrane into the fibrillar aggregates (B).</p

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