<i>C</i>‑Terminal Acetylene Derivatized Peptides <i>via</i> Silyl-Based Alkyne Immobilization

Abstract

A new Silyl-based Alkyne Modifying (SAM)-linker for the synthesis of <i>C</i>-terminal acetylene-derivatized peptides is reported. The broad scope of this SAM2-linker is illustrated by manual synthesis of peptides that are side-chain protected, fully deprotected, and disulfide-bridged. Synthesis of a 14-meric (KLAKLAK)₂ derivative by microwave-assisted automated SPPS and a one-pot cleavage click procedure yielding protected 1,2,3-triazole peptide conjugates are also described