NK cells contribute to the early up-regulation of CXCR3 ligands induced by poly I:C.

Abstract

<p>(A) C57BL/6 mice were treated with poly I:C by for the indicated amount of time. Left panels, surface staining for immune cell populations in the submandibular glands, with the gating indicated above the plots. Right panels, Percentage of NK1.1<sup>+</sup> TCR-β<sup>+</sup>, TCR-γδ<sup>+</sup>, CD4<sup>+</sup> and CD8<sup>+</sup> T cells among total submandibular gland cells. All data are the average of or representative of 5 individual mice (2-3 mice per experiment, total 2 independent experiments). (B) RAG-1<sup>-/-</sup> mice were pre-treated with anti-NK1.1 antibody 2 days prior to poly I:C injection. Submandibular glands were harvested 6 hours after poly I:C injection and measured for gene expression by real time PCR. Data are from analyses of 4 individual mice (2 mice per experiment, total 2 independent experiments). </p

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