Effect of actinomycin D on gene expression.

Abstract

<p>Effects of actinomycin D (<b>A</b>), epirubicin (<b>B</b>) doxorubicin (<b>C</b>), ebselen (<b>D</b>) and Erk inhibitor (<b>E</b>) on NR0B1-Luc (solid line) and UbC-Renilla (dotted line) reporter activity. Data plotted as mean +/βˆ’ SEM of triplicates. <b>F</b>: Quantitative RT-PCR was used to determine the abundance of NR0B1, TP53 and RPS26 mRNA after overnight treatment of A673 cells with the indicated concentrations of actinomycin D. Results normalized to DMSO control. Data plotted as mean +/βˆ’ SD of quadruplicates, and are representative of 3 independent experiments.</p

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