The length of the coding sequence and the mean number of rare alleles per gene.

Abstract

<p>In an average healthy individual from the 5000 exomes project there is more than one rare heterozygous variant in <i>MUC16</i> that has an allele frequency below 0.01 in the reference population. In contrast, the coding sequence of <i>PIGO</i> is much shorter and rare heterozygous variants occur in less than 8 out of 1000 exomes.</p