Sirt6 overexpression has no significant effect on glucose toerance in LTKO mice.

Abstract

<p>(A) Sirt6 overexpression was assessed by Western blot analysis in liver lysates from control and LTKO mice injected with SIRT6 or GFP adenoviruses (n=6). (B) Glucose tolerance tests in 4-month-old control and LTKO mice injected with SIRT6 or GFP adenoviruses (n=6). (C) Expression of genes involved in glucose metabolism was analyzed in the livers of SIRT6 or GFP adenovirus infected control and LTKO mice (n=6) by real-time PCR. Data represent mean ± SEM. * indicates a significance with <i>P</i><0.05 between loxp-GFP and loxp-SIRT6 groups.</p