LTKO mice maintain euglycemic and glucose tolerant on a high-fat diet.

Abstract

<p>(A) Fasting glucose levels in 4.5-month male control and LTKO mice (n=8) after the treatment with a high-fat diet for 3.5 months. (B) Non-fasting blood glucose levels in 4-month male control and LTKO mice (n=8) after the treatment with the high-fat diet for 3 months. (C, D) Glucose tolerance tests and the AUC analysis in 4.5-month male control and LTKO mice (n=8) after the treatment with the high-fat diet for 3.5 months, respectively. (E, F) Expression of genes involved in glucose metabolism was analyzed in the liver of control and LTKO mice (n=4) treated with the high-fat diet for 5 months by real-time PCR. <i>Pck1</i>, phosphoenoylpyruvate carboxykinase 1; <i>G6pc</i>, glucose-6-phosphatase, catalytic; <i>Pdk2</i>, pyruvate dehydrogenase kinase 2; <i>Gck</i>, glucokinase; <i>Pklr</i>, pyruvate kinase, liver and red blood cell type. Data represent mean ± SEM. * indicates a significance with <i>P</i><0.05 in control vs. LTKO mice.</p