Metal-Free Borane-Catalyzed Highly Stereoselective
Hydrogenation of Pyridines
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Abstract
A metal-free
direct hydrogenation of pyridines was successfully
realized by using homogeneous borane catalysts generated from alkenes
and HB(C<sub>6</sub>F<sub>5</sub>)<sub>2</sub> via in situ hydroboration.
The reaction affords a broad range of piperidines in high yields with
excellent cis stereoselectivities