Effects of the CysLT<sub>1</sub>R antagonist Montelukast on HT-29 and SW-480 xenograft tumor growth.

Abstract

<p>(<b>A</b>) Experimental protocol; untreated SW-480 or HT-29 cells were subcutaneously injected into both flanks of BalbC (nu/nu) mice. These mice received daily intraperitoneal injections with DMSO or Montelukast (5 mg/kg) for 14 days, starting 7 days after tumor cell inoculation. (<b>B</b>) Tumor weight and (<b>C</b>) volume at the experimental endpoint (day 21). (<b>D, E</b>) Tumor diameters over a 21-day period. (<b>F</b>) Representative <i>in situ</i> tumor images. The quantitative data shown are the mean ± SEM. *<i>P</i><0.05. Tumor volume and weight analysis was performed by Student’s <i>t</i> test and tumor diameter analysis was performed by two-way ANOVA.</p

    Similar works

    Full text

    thumbnail-image