<p>(A) The disiRNA distribution at <i>disi-47</i> locus in wild-type and <i>wc-2<sup>KO</sup></i> strain. Arrows indicate the transcription start sites. dLRE and pLRE are the two WC complex binding sites. The red bars indicate approximate primer set locations (see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003761#pgen.1003761.s009" target="_blank">Table S1</a> for primer sequences). (B) RT-qPCR analyses of <i>frq</i> mRNA. (C) RT-qPCR analyses of the transcripts in the <i>frq</i> promoter region from a wild-type strain grown in constant light (LL) or constant darkness (DD) conditions and the <i>wc-2<sup>KO</sup></i> strain grown in LL. (D) MeDIP results of the dLRE region in the wild-type (LL and DD conditions) and the <i>wc-2<sup>KO</sup></i> strains (LL). In (B), (C) and (D), three independent repeats were performed. Values are mean ± s.d.</p
