<p>(<b>A</b>–<b>B</b>) Effect of BQ788 on SMI-71 expression and ETB receptor expression 12 h after SE. (<b>C</b>) Effect of BQ788 on ET<sub>B</sub> receptor mRNA expression 12 h after SE (means ± s.e.m., n = 5, respectively); paired Student’s t-test. (<b>D</b>) Nitrate/nitrite (NO products) concentration in the PC after SE (mean ± s.d., n = 5): *P < 0.05 versus basal level; paired Student’s t-test. (<b>E</b>–<b>G</b>) Effects of BQ788 and Cav1-peptide on eNOS mRNA/protein expression 12 h after SE (means ± s.e.m., n = 5, respectively); *P < 0.05 versus non-SE animals; #P < 0.05 versus vehicle-treated animals; P < 0.05 versus BQ788-treated animals; one-way ANOVA followed by Tukey’s test. (H–J) Effects of of BQ788 and Cav1-peptide on eNOS, SMI-71 and NT expression 12 h after SE (means ± s.e.m., n = 5, respectively); *P < 0.05 versus non-SE animals; #P < 0.05 versus vehicle-treated animals; P < 0.05 versus BQ788-treated animals; one-way ANOVA followed by Tukey’s test. (<b>K</b>–<b>N</b>) Quantification of vasogenic edema formation 3days after SE (means ± s.e.m., n = 5, respectively); *P < 0.05 versus vehicle-treated animals; #P < 0.05 versus BQ788-treated animals; one-way ANOVA followed by Tukey’s test. Scale bars: <b>A, B, H</b> and <b>I</b>, 25 μm; <b>K-M</b>, 400 μm.</p
