Free-Amine Directed Arylation of Biaryl-2-amines with Aryl Iodides by Palladium Catalysis

Abstract

A new palladium-catalyzed free-amine directed arylation of C(sp²)–H bonds in the presence of AgOAc and TFA is described. Biaryl-2-amines react with various aryl iodides to give the corresponding mono- or diarylated products with exclusive regioselectivity