Matthews correlation coefficient (MCC) vs. choice of binary classification threshold for Datasets 1, 2, 3.

Abstract

<p>It is seen that there is a much higher and more distinct peak for Dataset 1, supporting the inference derived from the relative AUC scores (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0081100#pone-0081100-g001" target="_blank">Figures 1</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0081100#pone-0081100-g002" target="_blank">2</a>, and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0081100#pone-0081100-g003" target="_blank">3</a>) that the Dataset 1 provides the best differentiation between the interacting and non-interacting pairs.</p