Performance of male IL-1R1^−/− mice versus male WT on a battery of tasks.

Abstract

<p>(a) Visuo-spatial reference memory was assessed using the Y-maze across 20 trials (n = 5 per trial block) in male IL-1R1^−/− (n = 11) compared to male WT mice (n = 9). (b) The time spent freezing before (too small to be clearly visible), and 48 hours following, 0.4 mA foot shock for male IL-1R1^−/− mice and WT mice in the fear conditioning paradigm. (c) The number of squares crossed in 3 minutes in the open field and (d) the number of rears recorded in open field, across 3 minutes (e) the time spent in open arms of the elevated plus maze and (f) entries into open arms as a proportion of total arm entries (for male and females combined). Data are expressed as mean ± SEM and figure (a, b) were analysed by two way repeated-measures ANOVA with strain as between subjects factor and time/block as within subjects factor and all other figures were analysed by one-tailed t-test and significant differences are denoted by ** p<0.001 and *p<0.05.</p