<p>Immunodetection of CEP290 and acetylated tubulin in retinal sections from <i>Cep290</i><sup><i>wt/wt</i></sup>, <i>Cep290</i><sup><i>hum/hum</i></sup> and <i>Cep290</i><sup><i>lca/lca</i></sup> mice, at P150. Images were taken at 200X (A) and 400x (B) magnifications. CEP290 (green) is located in the connecting cilium (CC) and remains unaltered in the humanized models. Nuclei were marked with DAPI (blue) and CC with acetylated tubulin (red). GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer; PhL: photoreceptor layer; RPE: retinal pigment epithelium; IS: inner segment; CC: connecting cilium; OS: outer segment.</p
