Abstract

<p>Observations and analysis on mice were done four days post-infection. (A) Fungal load was expressed as log10 CFU/lung. (B) Lung histology (periodic acid-Schiff-staining). Note the polymorphonuclear cells and mononuclear infiltrates surrounding the bronchi in <i>ku80</i> infected lung. (C) After infection, percentages of monocytes and polymorphonuclear cells found in the lungs alveolar lavage (BAL). (D) Relative expression of TNFα and IL10 assessed by real time RT-PCR on lung total RNA from naïve and infected mice. (E) Conidiocidal activity by purified macrophages from uninfected mice expressed in percentage of CFU inhibition after 2 h incubation of the conidia with macrophages. Data are representative of at least three independent experiments. Ctl, naïve mice; *, P<0.05.</p

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