Pd-Catalyzed Desymmetric Intramolecular <i>O</i>‑Arylation Reaction: Enantioselective Synthesis of (3,4-Dihydro‑2<i>H</i>‑chromen-3-yl)methanols

Abstract

An enantioselective intramolecular <i>O</i>-arylation was achieved through desymmetrization with Pd-catalyzed coupling reactions. The intramolecular asymmetric aryl C–O coupling reactions of 2-(2-haloaryl)propane-1,3-diols led to the enantioselective formation of chiral (3,4-dihydro-2<i>H</i>-chromen-3-yl)methanols in good yields and high enantiomeric selectivity