Rh-Catalyzed Highly Enantioselective Hydroalkynylation Reaction of Norbornadiene Derivatives

Abstract

The complexes of various Rh precusors with ferrocenyl chiral ligand (<i>R</i>,<i>S</i>)-Cy₂PF-PPh₂ were found effective catalysts for the asymmetric hydroalkynylation reaction of norbornadiene derivatives. When RhCl₃·3H₂O was employed, good yields (up to 98%) and high enantioselectivities (up to >99.9% <i>ee</i>) could be obtained for the reactions of a broad scope of substrates