Description of simulation schemas.
- Publication date
- Publisher
Abstract
a<p>In each schema, three two-locus interaction models (additive × additive, dominant × dominant and recessive × recessive) were evaluated.</p>b<p><i>OR<sub>G</sub></i>, <i>OR<sub>H</sub></i>, and <i>OR<sub>GH</sub></i> denote the main effect for locus <i>G</i>, main effect for locus <i>H</i>, and their interaction effect, respectively. “√” indicates that the effect is present. “–” indicates that the effect is absent.</p>c<p>Disease prevalence (baseline penetrance).</p>d<p>For Schemas 8 and 9, the interaction effect <i>OR<sub>GH</sub></i> was increased from 1.0 to a value at which the power of the optimal metric achieved 100% at significance level 0.01.</p
