Average correlation vs. evolutionary span for Dataset 3.

Abstract

<p>A). Interacting protein pairs. B). Non-interacting protein pairs. The evolutionary span is defined as the time since last common ancestor for the most distantly related species in the data subset. Correlation scores are mean values for each different evolutionary span, error bar shown as the standard deviation of the correlation scores within respective correlation score range. Range of conservation is defined by the range of the relevant OMA orthology sets. Time since last common ancestor is derived from the TimeTree database <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0081100#pone.0081100-Hedges1" target="_blank">[35]</a>. It is seen that the mean score is lower and the standard deviation is larger for data subsets that contain only closely related species.</p