Untargeted multilevel principal component analysis performed on 1H-MRS spectra acquired on the whole lipid fraction of bone marrow and peripheral blood samples at the time of diagnosis.

Abstract

<p>(A) mPCA scores plot shows a clear separation on the second principal component (PC2) between BM and PB specimens. (B) Loadings plot for the second principal component depicts the most relevant discriminatory functional groups from BM (negative loadings) and PB (positive loadings) collected at diagnosis. Red areas in (B) indicate significantly different regions of the MRS spectra according to a point-by-point nonparametric Wilcoxon Rank Sum Test (p < 0.05).</p

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