uPAR expression controls cell migration.

Abstract

<p>uPAR-293 and V-293 cells efficiently migrate toward serum growth factors or EGF (GF). However, uPAR, when expressed, recruits and bridges fMLFRs and β1 integrin at the cell surface, thus driving pro-migratory signaling (upper panels). In fact, anti-uPAR antibodies (anti-uPAR), FPR1 desensitization by the W peptide (W Pep), inhibition of uPAR/β1 integrin interaction by P-25 peptide (P-25) or of specific cell signalling mediators block migration of uPAR-293 cells without affecting migration of uPAR-negative V-293 control cells (lower panels).</p