Hematoxylin and eosin staining in the anterior horn of spinal cord.
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Abstract
<p>(A) The sham group showed no specific histopathological change. (B) The I/R group showed marked vacuolization and significant loss of α-motor neurons. (C) The NS group showed a similar histopathological appearance to the I/R group. (E–H) Histopathological damage was attenuated in C<sub>0.01</sub>, C<sub>0.05</sub>, C<sub>0.1</sub>, and C<sub>0.5</sub> groups. The α-motor neurons were preserved most in the C<sub>0.1</sub> group. (D and I) The C<sub>0.005</sub> and C<sub>1</sub> groups showed no significant neuroprotection (original magnification, 40× object lens). I/R = ischemia-reperfusion; NS = normal saline; C<sub>0.005</sub>-C<sub>1</sub> = clenbuterol 0.005–1 mg/kg.</p
