Pregnant <i>Asb4<sup>−/−</sup></i> mice display symptoms of pre-eclampsia.

Abstract

<p>A) A subset of <i>Asb4<sup>−/−</sup></i> embryos dies <i>in utero</i>. <i>Asb4<sup>−/−</sup></i> littermates are shown at E12.5, illustrating the lack of placental vasculature and dramatically reduced fetal growth in a subset of <i>Asb4<sup>−/−</sup></i> embryos. The resultant average litter size, taken from more than 25 litters from each group, is quantified in B. C) Heterozygous breeding results in a lower than expected number of <i>Asb4<sup>−/−</sup></i> pups (p<0.01, Fisher’s exact test). Pregnant <i>Asb4<sup>−/−</sup></i> mice have significantly elevated mean blood pressure (D) and urine-albumin:urine-creatinine (E) in the third trimester of pregnancy compared with both <i>Asb4<sup>−/−</sup></i> mice in the first week of pregnancy and wild-type mice in the third week of pregnancy. * p<0.01.</p

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