<p>B6 mice were infected with LCMV or left uninfected for 45 days. Mice in each group were then treated with CD8-depleting antibody every 3 days for 15 days or left untreated. Blood was taken from animals in each group prior to <i>L. major</i> infection to assess CD8 depletion efficiency (A) and at 4 weeks post <i>L. major</i> infection to monitor reconstitution of the CD8 T cell compartment (B). All mice were with metacyclic <i>L. major</i> and ear thickness was measured weekly (C). Pictures were taken 4 weeks post <i>L. major</i> infection (D). Infected skin was taken at 4 weeks post infection and parasite burden was assessed using a limiting dilution assay (F). Infected skin was analyzed 4 weeks after <i>L. major</i> infection and the number of CD8 T cells present in each group was calculated (E). Data are representative of two independent experiments (n = 10 per group).</p
