Comparison of sequence patterns in TK-specific motifs.

Abstract

<p><b>A</b>. Sub-domains of the protein kinase domain. Consensus sequences DL(R/A)A(A/R)N in subdomain VI and XP(I/V)(K/R)W(T/M)APE in subdomain VIII are specific to TKs. The motif in red [GXR(M/L)] was identified in this study. The motif CW(X)₆RPXF in gray was found to be not specific to TKs in this study (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0089813#pone.0089813.s002" target="_blank">Figure S2</a>). <b>B</b>. The LOGOs show sequence patterns of the three motifs in each group. Red arrow heads indicate conserved amino acid residues that are diagnostic for TKs.</p