Experimental and Theoretical
Study of the Emergence
of Single Chirality in Attrition-Enhanced Deracemization
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Abstract
Experimental studies help to deconvolute
the driving forces for
crystal growth during attrition-enhanced deracemization, demonstrating
an interplay between crystal size and crystal number in the emergence
of homochirality. A semiempirical population balance model is presented
based on considerations of the solubility driving force, as outlined
by the Gibbs–Thomson rule, and a frequency factor based on
the total interfacial surface area between solid crystals and the
solution phase