2‑Aminopyridines via Reaction of Pyridine <i>N</i>‑Oxides and Activated Isocyanides

Abstract

A practical and efficient method for the synthesis of substituted 2-aminopyridines from pyridine <i>N</i>-oxides is reported. Yields of purified, isolated products of up to 84% are observed for the one-pot, two-step process. The reaction involves an in situ deprotection of an isolable <i>N</i>-formylaminopyridine intermediate and facilitates the synthesis of 2-aminopyridines for which other methods fail