Mutual
Induced Fit in a Synthetic Host–Guest
System
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Abstract
Mutual
induced fit is an important phenomenon in biological molecular
recognition, but it is still rare in artificial systems. Here we report
an artificial host–guest system in which a flexible calix[4]arene
is enclathrated in a dynamic self-assembled host and both molecules
mutually adopt specific three-dimensional structures. NMR data revealed
the conformational changes, and crystallographic studies clearly established
the precise structures at each stage