Effects of S100A7 overexpression on mitochondrial dynamics and autophagy activation.
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Abstract
<p>S100A7-HaCaT cells were treated for 24 h with LPS at 100 and 1000 ng/ml. (<b>A</b>, <b>B</b>) The mitochondrial dynamics-related proteins Mfn1, Mfn2 and DRP1 and (<b>C</b>, <b>D</b>) the autophagy-related proteins Beclin1 and LC3B were detected by Western blot (<b>A</b>, <b>C</b> western blot images; <b>B</b>, <b>D</b> statistical results). Values are means ± SEM. Statistical significance is indicated (*<i>P</i><0.05, **<i>P</i><0.01, ***<i>P</i><0.001, <sup>#</sup><i>P</i><0.05, ∧∧<i>P</i><0.01, ∧∧∧<i>P</i><0.001). veh, vehicle; veh-100 or veh-1000, vehicle with 100 or 1000 ng/ml LPS treatment; pso, S100A7; pso-100 or pso-1000, S100A7-EGFP HaCaT cells with 100 or 1000 ng/ml LPS treatment.</p
