Modulation of APP processing by HLJDT and HLJDT-M in N2a-SwedAPPcells.

Abstract

<p>Conditioned medium and cell lysates were prepared from N2a-SwedAPP cells that were treated with (A) HLJDT or (B) HLJDT-M at various doses as indicated for 48 h. Western blotting was used to detect sAPPα and sAPPβ-sw in conditioned medium, and to detect Fl-APP, pAPPThr668, CTFs and β-actin in cell lysates. Bars represent mean±S.E.M. for three experiments. One-way ANOVA revealed significant differences due to treatment at various doses of HLJDT or HLJDT-M: *p<0.05; **p<0.01; ***p<0.001.</p