Comparison of coupled-ICD and conventional approaches for detecting group-by-condition interaction for cocaine-dependent subjects (CD) and healthy controls (HC).

Abstract

<p>As the comparison between CD and HC subjects involves contrasting a metric (coupled-ICD) that already measures the difference between two conditions, this result can be interpreted in a similar manner to the interaction term of a classic 2×2 two-way ANOVA. A) Coupled-ICD detected more widespread significant interactions than the two conventional approaches, B) ICD and C) wGBC. D) ROI-based matrix connectivity method also detects widespread interaction between group and condition provide support that the coupled-ICD results are not simply artifacts. Only edges that were significantly difference at p<0.05 with FDR correction are shown. The size of the node is proportional to the number of significantly different edges touching that node. A larger node has more significantly different edges.</p