The effect of IRAK1/4 inhibitor on the expansion of Th1 cells and Th17 cells.

Abstract

<p>Purified CD4⁺T cells from normal controls (n = 8) were cultured with or without IRAK1/4 inhibitor for 3 days in the presence of wither IL-18 or IL-1β. The frequency of Th1 and Th17 cells was analyzed by FCM. <b>A</b>. A representative patient with data near the mean of each group in B and C. <b>B</b>. The results represent the percentages of IFN-γ⁺, IL-17⁺, and IL-17⁺IFN-γ⁺ cells among the CD4⁺T cells in the presence of IL-18. Results are expressed as means ± SD. <b>C</b>. The results represent the percentages of IFN-γ⁺,IL-17⁺, and IL-17⁺IFN-γ⁺ cells among the CD4⁺T cells in the presence of IL-1β. Results are expressed as means ± SD.</p