<p>Bars represent the log<sub>2</sub>-ratio of the entries in the Jacobian matrices of Col-0 under conditions of light (L) and extended night (EN), which were derived from covariance data of metabolomics data sets. Blue colour indicates a ratio >1, i.e. the Jacobian entry of the samples of extended night was higher than under normal light. White colour indicates a ratio <1, i.e. the Jacobian entry of the samples of extended night was lower than under normal light. All entries represent median values of 10<sup>3</sup> calculations normalised to the square of interquartile distance. (<b>A</b>) and characterize the entries of the Jacobian matrix and refer to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0092299#pone.0092299.e001" target="_blank">equation 1</a>. (<b>B</b>) shows the diagonal entries of the Jacobian matrix belonging to the metabolites described on the horizontal axis.</p