Abstract

<p>Simplified schematic of the IRF3-NF-κB model. Only dsRNA, proteins (in the cytoplasm) and genes (in the nucleus) are shown. Solid green lines on the top denote direct chemical binding. Green dotted lines denote activation. Vertical thick colored arrows denote translocation of activated transcription factors into the nucleus. Red dotted lines denote inhibition. Horizontal solid black arrows in the nucleus denote gene transcription, with plus or minus signs denoting activation or repression, respectively. Transcripts and inactive forms of the proteins are omitted for simplicity.</p

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